Our Resident and Alumni are Hiring!

Open Positions:

Facility Laboratory Assistant (Part Time)


We seek an energetic and motivated part-time facility laboratory assistant. A successful candidate will have proven time management skills and the ability to work independently. Under the supervision of the Site Manager, the facility laboratory assistant will proactively complete regular maintenance and cleaning tasks, while ensuring compliance with laboratory rules and regulations.

• Handle laboratory cleaning responsibilities including countertops, equipment and glassware
• Assist Laboratory Operations Manager with day-to-day laboratory operations, including monitoring and changing of compressed gas cylinders
• Assist with the storage and disposal of hazardous waste while making sure safe handling procedures are always followed • Handle shipping and receiving tasks
• Perform other duties as may be required Schedule:
• Part-time, with a target of 10 hours per week

Apply by emailing resume to frontdesk@nest.bio or here 

Clinical Trial Associate (Full Time)

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The Clinical Trial Associate (CTA) provides clinical trial coordination support to Project Teams for assigned clinical trial(s). This support includes tracking a wide range of key operational activities and maintenance of essential study documentation, including the electronic Trial Master File (eTMF). This position will work with internal team members and with external vendors and CROs. The position reports to the Clinical Operations AD or above and will work cross-functionally and collaboratively to support clinical operations activities for a product’s development.

• Assist the Clinical Trial Manager(s) (CTM) in the day-to-day operational activities of assigned trials to ensure study objectives and timelines are met with consistently high quality, in compliance with applicable SOPs and regulatory guidelines.
• Maintain clinical trial files (including eTMF), project processes, tracking systems, and other utilized study or departmental systems.
• Liaise with Clinical Sample Management for the tracking and coordination of biomarker testing with 3rd party labs/central labs.
• Collaborate with CRO/appropriate vendors to ensure timely training and access to necessary systems (e.g., EDC, IWRS, ePRO, eTMF) for external stakeholders (e.g., CRO and Clinical Site Staff).
• Coordinate Project Team and departmental meetings, including associated documentation.
• Assist with vendor / clinical site agreements, budgets and reconciliation / tracking of purchase orders and invoices for assigned trials.
• Develop and maintain strong, collaborative relationships with key stakeholders within the organization, its CROs and vendors, and clinical sites.

Apply Here

Senior Research Associate / Scientist, AAV Downstream Process Development


We are seeking a senior research associate /scientist for AAV downstream process development to join our growing AAV group at Cambridge, MA. The successful candidate is responsible for developing and optimizing the downstream AAV process development including design and implementation of chromatographic, filtration and centrifugation studies, performance qualification, process characterization and control strategies, and tech transfer to contract manufacturing organizations (CMO). The candidate will be a crucial member of the AAV group for developing AAV process development and manufacturing strategies for our leading projects.

• Lead and support downstream activities during process development, preclinical, clinical, and potentially commercial manufacturing
• Develop and optimize chromatography processes (including affinity, IEX, HIC, SEC, etc.) and filtration processes (depth filtration, UF/DF, tangential flow filtration, sterile filtration, etc.)
• Plan, design, and execute purification development experimental studies using DOE to define process parameters, ranges, specifications, and control strategies for establishing a robust and reliable purification process
• Explore and develop innovative downstream process technologies to improve AAV platforms
• Pilot and optimize process scale-up, manufacturing operations, and deviations/investigations
• Lead tech-transfer activities to contract manufacturing organizations
• Maintain electronic lab notebooks and author development reports
• Strong team player to collaborate with vector engineering, upstream process development, and analytical assay development teams

Apply Here

Head of High Throughput RNA Pharmacology (Full Time)


Laronde is seeking a Head of High Throughput Pharmacology functional area within Platform Group to build and provide leadership for a team focusing on design and implementation of high throughput screening of large RNA constructs. The candidate will develop and lead implementation of strategies and assays toward characterizing eRNA using cell and biochemical assays in a high throughput format, building understanding of eRNA pharmacology and the effects of construct and process design elements on translation. The candidate will interface and collaborate with teams within therapeutics area research, discovery biology, and manufacturing groups to advance platform research and therapeutic area research programs. We are searching for driven, enthusiastic and self-motivated individuals who are comfortable multitasking and working independently on various aspects of the platform.

• Develop a team focused on high throughput approaches to characterizing eRNA in vitro pharmacology
• Lead design and execution of cellular and biochemical assays to drive real time decision making with rapid and high quality data in support of Laronde objectives
• Interface closely with computational molecular biology scientists to drive understanding of eRNA structure effects on stability and translation
• Interface closely with research, preclinical manufacturing and automation teams to ensure timely characterization of preclinical pipeline constructs
• Provide scientific leadership by coordinating activities with teams across diverse backgrounds
• Oversee and provide scientific direction to multiple direct reports
• Maintain scientific and technical expertise through familiarity with scientific literature, attending conferences, and developing relationships with thought leaders
• Work closely with an entrepreneurial, highly-collaborative, interdisciplinary team and actively contribute to creating, shaping and executing the scientific vision of the company

Apply Here